Procyanidin B-2 and the Hair-Growing Activity of Proanthocyanidins
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چکیده
منابع مشابه
Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair-growing agent.
BACKGROUND Procyanidins are a family of condensed tannins, which have been shown to possess hair-growing activity in both the in vitro and in vivo murine models. AIMS We report a 12-month clinical study aimed at treating male pattern baldness by external application of 0.7% apple procyanidin oligomers. PATIENTS/METHODS A double-blind clinical test involving a total of 43 subjects was perfor...
متن کاملProcyanidin B-2, extracted from apples, promotes hair growth: a laboratory study.
BACKGROUND We have previously reported that several selective protein kinase C (PKC) inhibitors, including procyanidin B-2, promote hair epithelial cell growth and stimulate anagen induction. OBJECTIVES We discuss the hypothesis that the hair-growing activity of procyanidin B-2 is related to its downregulation or inhibition of translocation of PKC isozymes in hair epithelial cells. METHODS ...
متن کاملThe first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent.
Procyanidin B-2 is a compound we have identified in apple which acts as a growth-promoting factor on murine hair epithelial cells. This report describes our investigation of the hair-growing effects of 1% procyanidin B-2 tonic after sequential use for 4 months. A double-blind clinical trial was performed, involving a total of 29 subjects (procyanidin B-2, 19 men; placebo, 10 men). No adverse si...
متن کاملIdentification of Proanthocyanidins from Litchi (Litchi chinensis Sonn.) Pulp by LC-ESI-Q-TOF-MS and Their Antioxidant Activity
Content of total proanthocyanidins as well as total phenolics, flavonoids, antioxidant activities were evaluated for litchi (Litchi chinensis Sonn.) pulp of 32 cultivars. One cultivar, Hemaoli, showed the highest total proanthocyanidins and total phenolics, and DPPH or ABTS radical scavenging activities. ESI-MS and NMR analysis of the Hemaoli pulp crude extracts (HPCE) showed that procyandins c...
متن کاملProanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo.
For the purpose of discovering natural products which possess hair growing activity, we examined about 1000 kinds of plant extracts concerning growth-promoting activity with respect to hair follicle cells. After an extensive search, we discovered that proanthocyanidins extracted from grape seeds promote proliferation of hair follicle cells isolated from mice by about 230% relative to controls (...
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